1.1 Neurogenesis in the adult and developing brain.
I focus on new neurons that are continually generated throughout adulthood in predominantly two regions of the brain, especially, the subgranular zone (SGZ) of the dentate gyrus in the hippocampus.
1.2 Application of bioactive compounds from Thai plants in biomedical research.
I am interested in the antioxidant effect of Thai plants on neural stem cells in the hippocampal dentate gyrus that is associated with memory, anti-aging and anti-cancer.
Sirichoat A,Suwannakot K, Chaisawang P, Pannangrong W, Aranarochana A, Wigmore P, et al. Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats. Life sciences. 2020:117468.
Sritawan N, Prajit R, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, et al. Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model. Biomed Pharmacother. 2020;131:110651.
Prajit R, Sritawan N, Suwannakot K, Naewla S, Aranarochana A, Sirichoat A,et al. Chrysin Protects against Memory and Hippocampal Neurogenesis Depletion in D-Galactose-Induced Aging in Rats. Nutrients. 2020 Apr 16;12(4). PubMed PMID: 32316121.
Sirichoat A, Krutsri S, Suwannakot K, Aranarochana A, Chaisawang P, Pannangrong W, Wigmore P, Welbat JU (2019) Melatonin protects against methotrexate-induced memory deficit and hippocampal neurogenesis impairment in a rat model. Biochemical pharmacology 163:225-233.
Aranarochana A, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, Welbat JU (2019) Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis. Neuroscience 406:580-593.
Naewla S, Sirichoat A, Pannangrong W, Chaisawang P, Wigmore P, Welbat JU (2019) Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats. Nutrients 11.
Pannangrong W, Sirichoat A, Wongsiri T, Wigmore P, Welbat JU (2019) Valproic acid withdrawal ameliorates impairments of hippocampal-spatial working memory and neurogenesis. J Zhejiang Univ-Sc B 20:253-263.
Chaisawang, P., A. Sirichoat, W. Chaijaroonkhanarak, W. Pannangrong, B. Sripanidkulchai, P. Wigmore and J. U. Welbat (2017). "Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy." PLoS One 12(7): e0180650.
Umka Welbat, J., A. Sirichoat, W. Chaijaroonkhanarak, P. Prachaney, W. Pannangrong, P. Pakdeechote, B. Sripanidkulchai and P. Wigmore (2016). "Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and Survival." Nutrients 8(5).
Welbat, J. U., P. Sangrich, A. Sirichoat, P. Chaisawang, W. Chaijaroonkhanarak, P. Prachaney, W. Pannangrong and P. Wigmore (2016). "Fluoxetine prevents the memory deficits and reduction in hippocampal cell proliferation caused by valproic acid." J Chem Neuroanat 78: 112-118.
Sirichoat A, Chaijaroonkhanarak W, Prachaney P, Pannangrong W, Leksomboon R, Chaichun A, et al. Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus. Nutrients 2015; 7: 8413-23.